Dialysis modality and cognitive outcomes in chronic kidney disease: a systematic review and meta-analysis.

ABSTRACT:

Background

Cognitive impairment is a prevalent comorbidity in patients with chronic kidney disease (CKD). While hemodialysis (HD) and peritoneal dialysis (PD) are established renal replacement therapies, their relative effects on cognitive outcomes remain unclear. This meta-analysis compared cognitive outcomes between HD and PD in CKD patients.

Methods

The protocol was prospectively registered on PROSPERO (CRD42024602533). PubMed, CENTRAL, Embase, Medline, Web of Science, PsychInfo, and CINAHL were searched from January 2000 to January 2025. Eligible studies included cohort studies of adult patients undergoing HD versus PD. Primary outcomes were cognitive function and dementia incidence. A random-effects meta-analysis model was used. Risk of bias was assessed using ROBINS-I,

SUBMITTER: Malik A 

PROVIDER: S-EPMC12950099 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature