A novel Chinese medicine formula against hyperuricemia-induced kidney inflammation involving pyroptosis inhibition via modulating AMPK-TLR4-NLRP3 pathway.

ABSTRACT:

Background

Hyperuricemia (HUA), characterized by elevated serum uric acid (SUA) level, serves as a precursor of gout. Gout formula (GF), an empirical formula, has been prescribed in Chinese medicine practice for many years and observed to be effective in relieving HUA and gout. This study aimed to investigate GF as an innovative therapeutic agent for HUA and to elucidate its underlying molecular mechanisms using in vivo and in vitro models of HUA.

Methods

A HUA mouse model was established by orally administering potassium oxonate (PO) and injecting with hypoxanthine (HX) to mice. Behavioral tests and histopathological analysis were performed to measure the efficacy of GF. Biochemical indicators such as SUA, urine uric acid (UA), xanthine oxidase (XOD), blood urea nitrogen (B

SUBMITTER: Tian YY 

PROVIDER: S-EPMC12950236 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature