Assessing the spatiotemporal evolution of neuronal activation with single-trial event-related potentials and functional MRI.

ABSTRACT: The brain acts as an integrated information processing system, which methods in cognitive neuroscience have so far depicted in a fragmented fashion. Here, we propose a simple and robust way to integrate functional MRI (fMRI) with single trial event-related potentials (ERP) to provide a more complete spatiotemporal characterization of evoked responses in the human brain. The idea behind the approach is to find brain regions whose fMRI responses can be predicted by paradigm-induced amplitude modulations of simultaneously acquired single trial ERPs. The method was used to study a variant of a two-stimulus auditory target detection (odd-ball) paradigm that manipulated predictability through alternations of stimulus sequences with random or regular target-to-target intervals. In addition to ele

SUBMITTER: Eichele T 

PROVIDER: S-EPMC1295592 | biostudies-literature | 2005 Dec

REPOSITORIES: biostudies-literature