Brain lactate kinetics: Modeling evidence for neuronal lactate uptake upon activation.

ABSTRACT: A critical issue in brain energy metabolism is whether lactate produced within the brain by astrocytes is taken up and metabolized by neurons upon activation. Although there is ample evidence that neurons can efficiently use lactate as an energy substrate, at least in vitro, few experimental data exist to indicate that it is indeed the case in vivo. To address this question, we used a modeling approach to determine which mechanisms are necessary to explain typical brain lactate kinetics observed upon activation. On the basis of a previously validated model that takes into account the compartmentalization of energy metabolism, we developed a mathematical model of brain lactate kinetics, which was applied to published data describing the changes in extracellular lactate levels upon activatio

SUBMITTER: Aubert A 

PROVIDER: S-EPMC1297516 | biostudies-literature | 2005 Nov

REPOSITORIES: biostudies-literature