Microarray analysis identifies Salmonella genes belonging to the low-shear modeled microgravity regulon.

ABSTRACT: The low-shear environment of optimized rotation suspension culture allows both eukaryotic and prokaryotic cells to assume physiologically relevant phenotypes that have led to significant advances in fundamental investigations of medical and biological importance. This culture environment has also been used to model microgravity for ground-based studies regarding the impact of space flight on eukaryotic and prokaryotic physiology. We have previously demonstrated that low-shear modeled microgravity (LSMMG) under optimized rotation suspension culture is a novel environmental signal that regulates the virulence, stress resistance, and protein expression levels of Salmonella enterica serovar Typhimurium. However, the mechanisms used by the cells of any species, including Salmonella, to sense an

SUBMITTER: Wilson JW 

PROVIDER: S-EPMC129779 | biostudies-literature | 2002 Oct

REPOSITORIES: biostudies-literature