Antibodies against human cytomegalovirus in the pathogenesis of systemic sclerosis: a gene array approach.

ABSTRACT:

Background

Systemic sclerosis is an autoimmune disease characterized by immunological abnormalities, vascular damage, and fibroblast proliferation. We have previously shown that a molecular mimicry mechanism links antibodies against the human-cytomegalovirus-derived protein UL94 to the pathogenesis of systemic sclerosis. The UL94 epitope shows homology with NAG-2, a surface molecule highly expressed on endothelial cells. Anti-UL94 peptide antibodies purified from patients' sera induce apoptosis of endothelial cells upon engagement of the NAG-2-integrin complex.

Methods and findings

We show here that NAG-2 is expressed on dermal fibroblasts and that anti-UL94 antibodies bind to fibroblasts. We have used the gene array strategy (Affimetrix oligonucleotide microarrays) to analy

SUBMITTER: Lunardi C 

PROVIDER: S-EPMC1298939 | biostudies-literature | 2006 Jan

REPOSITORIES: biostudies-literature