Regulation of freA, acoA, lysF, and cycA expression by iron availability in Aspergillus nidulans.

ABSTRACT: In the filamentous fungus Aspergillus nidulans, iron homeostasis is regulated at the transcriptional level by the negative-acting GATA factor SREA. In this study the expression of a putative heme-containing metalloreductase-encoding gene, freA, was found to be upregulated by iron limitation independently of SREA, demonstrating the existence of an iron-regulatory mechanism which does not involve SREA. In contrast to freA, various other genes encoding proteins in need of iron-containing cofactors-acoA, lysF, and cycA-were downregulated in response to iron depletion. Remarkably, SREA deficiency led to increased expression of acoA, lysF, and cycA under iron-replete growth conditions.

SUBMITTER: Oberegger H 

PROVIDER: S-EPMC129941 | biostudies-literature | 2002 Nov

REPOSITORIES: biostudies-literature