SNP frequency, haplotype structure and linkage disequilibrium in elite maize inbred lines.

ABSTRACT:

Background

Recent studies of ancestral maize populations indicate that linkage disequilibrium tends to dissipate rapidly, sometimes within 100 bp. We set out to examine the linkage disequilibrium and diversity in maize elite inbred lines, which have been subject to population bottlenecks and intense selection by breeders. Such population events are expected to increase the amount of linkage disequilibrium, but reduce diversity. The results of this study will inform the design of genetic association studies.

Results

We examined the frequency and distribution of DNA polymorphisms at 18 maize genes in 36 maize inbreds, chosen to represent most of the genetic diversity in U.S. elite maize breeding pool. The frequency of nucleotide changes is high, on average one polymorphism per

SUBMITTER: Ching A 

PROVIDER: S-EPMC130040 | biostudies-literature | 2002 Oct

REPOSITORIES: biostudies-literature