First principles predictions of the structure and function of g-protein-coupled receptors: validation for bovine rhodopsin.

ABSTRACT: G-protein-coupled receptors (GPCRs) are involved in cell communication processes and with mediating such senses as vision, smell, taste, and pain. They constitute a prominent superfamily of drug targets, but an atomic-level structure is available for only one GPCR, bovine rhodopsin, making it difficult to use structure-based methods to design receptor-specific drugs. We have developed the MembStruk first principles computational method for predicting the three-dimensional structure of GPCRs. In this article we validate the MembStruk procedure by comparing its predictions with the high-resolution crystal structure of bovine rhodopsin. The crystal structure of bovine rhodopsin has the second extracellular (EC-II) loop closed over the transmembrane regions by making a disulfide linkage betwee

SUBMITTER: Trabanino RJ 

PROVIDER: S-EPMC1304048 | biostudies-literature | 2004 Apr

REPOSITORIES: biostudies-literature