The JAK-STAT signaling network in the human B-cell: an extreme signaling pathway analysis.

ABSTRACT: Large-scale models of signaling networks are beginning to be reconstructed and corresponding analysis frameworks are being developed. Herein, a reconstruction of the JAK-STAT signaling system in the human B-cell is described and a scalable framework for its network analysis is presented. This approach is called extreme signaling pathway analysis and involves the description of network properties with systemically independent basis vectors called extreme pathways. From the extreme signaling pathways, emergent systems properties of the JAK-STAT signaling network have been characterized, including 1), a mathematical definition of network crosstalk; 2), an analysis of redundancy in signaling inputs and outputs; 3), a study of reaction participation in the network; and 4), a delineation of 85 c

SUBMITTER: Papin JA 

PROVIDER: S-EPMC1304358 | biostudies-literature | 2004 Jul

REPOSITORIES: biostudies-literature