A Brownian dynamics study: the effect of a membrane environment on an electron transfer system.

ABSTRACT: During the past few years, three-dimensional crystal structures of many of the important integral membrane proteins responsible for the bioenergetic processes of photosynthesis and respiration have been determined. Moreover, a few crystal structures of protein-protein complexes have become available that characterize the interaction between those membrane proteins and the electron carrier protein cytochrome c. Here, we address the association kinetics for binding of cytochrome c to cytochrome c oxidase (COX) from Paracoccus denitrificans by Brownian dynamics simulations. The effects of ionic strength and protein mutations were studied for two different cytochrome c species: the positively charged, dipolar horse heart cytochrome c and the negatively charged physiological electron transfer p

SUBMITTER: Flock D 

PROVIDER: S-EPMC1304388 | biostudies-literature | 2004 Jul

REPOSITORIES: biostudies-literature