Multiphysics simulation of left ventricular filling dynamics using fluid-structure interaction finite element method.

ABSTRACT: To relate the subcellular molecular events to organ level physiology in heart, we have developed a three-dimensional finite-element-based simulation program incorporating the cellular mechanisms of excitation-contraction coupling and its propagation, and simulated the fluid-structure interaction involved in the contraction and relaxation of the human left ventricle. The FitzHugh-Nagumo model and four-state model representing the cross-bridge kinetics were adopted for cellular model. Both ventricular wall and blood in the cavity were modeled by finite element mesh. An arbitrary Lagrangian Eulerian finite element method with automatic mesh updating has been formulated for large domain changes, and a strong coupling strategy has been taken. Using electrical analog of pulmonary circulation and

SUBMITTER: Watanabe H 

PROVIDER: S-EPMC1304609 | biostudies-literature | 2004 Sep

REPOSITORIES: biostudies-literature