Phase resetting and phase locking in hybrid circuits of one model and one biological neuron.

ABSTRACT: To determine why elements of central pattern generators phase lock in a particular pattern under some conditions but not others, we tested a theoretical pattern prediction method. The method is based on the tabulated open loop pulsatile interactions of bursting neurons on a cycle-by-cycle basis and was tested in closed loop hybrid circuits composed of one bursting biological neuron and one bursting model neuron coupled using the dynamic clamp. A total of 164 hybrid networks were formed by varying the synaptic conductances. The prediction of 1:1 phase locking agreed qualitatively with the experimental observations, except in three hybrid circuits in which 1:1 locking was predicted but not observed. Correct predictions sometimes required consideration of the second order phase resetting, whi

SUBMITTER: Oprisan SA 

PROVIDER: S-EPMC1304653 | biostudies-literature | 2004 Oct

REPOSITORIES: biostudies-literature