Atomic model of the Thermus thermophilus 70S ribosome developed in silico.

ABSTRACT: The ribosome is a large molecular complex that consists of at least three ribonucleic acid molecules and a large number of proteins. It translates genetic information from messenger ribonucleic acid and makes protein accordingly. To better understand ribosomal function and provide information for designing biochemical experiments require knowledge of the complete structure of the ribosome. For expanding the structural information of the ribosome, we took on the challenge of developing a detailed Thermus thermophilus ribosomal structure computationally. By combining information derived from the low-resolution x-ray structure of the 70S ribosome (providing the overall fold), high-resolution structures of the ribosomal subunits (providing the local structure), sequences, and secondary structu

SUBMITTER: Tung CS 

PROVIDER: S-EPMC1304690 | biostudies-literature | 2004 Oct

REPOSITORIES: biostudies-literature