Molecular modeling of nearly full-length ErbB2 receptor.

ABSTRACT: Members of the epidermal growth factor receptor family play important roles in various cellular processes, both in physiological and in pathological conditions. Dimerization and autophosphorylation of these receptor tyrosine kinases are key events of signal transduction. Details of the molecular events of the signaling are not entirely known. To facilitate the understanding of receptor structure and function at the molecular level, a molecular model was built for the nearly full-length ErbB2 dimer. Modeling was based on the x-ray or nuclear-magnetic resonance structures of extracellular, transmembrane, and intracellular domains. The extracellular domain was positioned above the cell membrane based on the distance determined from experimentally measured fluorescence resonance energy transfe

SUBMITTER: Bagossi P 

PROVIDER: S-EPMC1305137 | biostudies-literature | 2005 Feb

REPOSITORIES: biostudies-literature