Genotypic diversity of clinical Actinomyces species: phenotype, source, and disease correlation among genospecies.

ABSTRACT: We determined the frequency distribution of Actinomyces spp. recovered in a routine clinical laboratory and investigated the clinical significance of accurate identification to the species level. We identified 92 clinical strains of Actinomyces, including 13 strains in the related Arcanobacterium-Actinobaculum taxon, by 16S rRNA gene sequence analysis and recorded their biotypes, sources, and disease associations. The clinical isolates clustered into 21 genogroups. Twelve genogroups (74 strains) correlated with a known species, and nine genogroups (17 strains) did not. The individual species had source and disease correlates. Actinomyces turicensis was the most frequently isolated species and was associated with genitourinary tract specimens, often with other organisms and rarely with infl

SUBMITTER: Clarridge JE 

PROVIDER: S-EPMC130750 | biostudies-literature | 2002 Sep

REPOSITORIES: biostudies-literature