A reference database for tumor-related genes co-expressed with interleukin-8 using genome-scale in silico analysis.

ABSTRACT:

Background

The EST database provides a rich resource for gene discovery and in silico expression analysis. We report a novel computational approach to identify co-expressed genes using EST database, and its application to IL-8.

Results

IL-8 is represented in 53 dbEST cDNA libraries. We calculated the frequency of occurrence of all the genes represented in these cDNA libraries, and ranked the candidates based on a Z-score. Additional analysis suggests that most IL-8 related genes are differentially expressed between non-tumor and tumor tissues. To focus on IL-8's function in tumor tissues, we further analyzed and ranked the genes in 16 IL-8 related tumor libraries.

Conclusions

This method generated a reference database for genes co-expressed with IL-8 and could facilit

SUBMITTER: Benbow L 

PROVIDER: S-EPMC131052 | biostudies-literature | 2002 Oct

REPOSITORIES: biostudies-literature