Genes involved in complex adaptive processes tend to have highly conserved upstream regions in mammalian genomes.

ABSTRACT:

Background

Recent advances in genome sequencing suggest a remarkable conservation in gene content of mammalian organisms. The similarity in gene repertoire present in different organisms has increased interest in studying regulatory mechanisms of gene expression aimed at elucidating the differences in phenotypes. In particular, a proximal promoter region contains a large number of regulatory elements that control the expression of its downstream gene. Although many studies have focused on identification of these elements, a broader picture on the complexity of transcriptional regulation of different biological processes has not been addressed in mammals. The regulatory complexity may strongly correlate with gene function, as different evolutionary forces must act on the regulatory

SUBMITTER: Lee S 

PROVIDER: S-EPMC1310621 | biostudies-literature | 2005 Nov

REPOSITORIES: biostudies-literature