The EH1 motif in metazoan transcription factors.

ABSTRACT:

Background

The Engrailed Homology 1 (EH1) motif is a small region, believed to have evolved convergently in homeobox and forkhead containing proteins, that interacts with the Drosophila protein groucho (C. elegans unc-37, Human Transducin-like Enhancers of Split). The small size of the motif makes its reliable identification by computational means difficult. I have systematically searched the predicted proteomes of Drosophila, C. elegans and human for further instances of the motif.

Results

Using motif identification methods and database searching techniques, I delimit which homeobox and forkhead domain containing proteins also have likely EH1 motifs. I show that despite low database search scores, there is a significant association of the motif with transcription factor fun

SUBMITTER: Copley RR 

PROVIDER: S-EPMC1310626 | biostudies-literature | 2005 Nov

REPOSITORIES: biostudies-literature