Computational identification of strain-, species- and genus-specific proteins.

ABSTRACT:

Background

The identification of unique proteins at different taxonomic levels has both scientific and practical value. Strain-, species- and genus-specific proteins can provide insight into the criteria that define an organism and its relationship with close relatives. Such proteins can also serve as taxon-specific diagnostic targets.

Description

A pipeline using a combination of computational and manual analyses of BLAST results was developed to identify strain-, species-, and genus-specific proteins and to catalog the closest sequenced relative for each protein in a proteome. Proteins encoded by a given strain are preliminarily considered to be unique if BLAST, using a comprehensive protein database, fails to retrieve (with an e-value better than 0.001) any protein not en

SUBMITTER: Mazumder R 

PROVIDER: S-EPMC1310627 | biostudies-literature | 2005 Nov

REPOSITORIES: biostudies-literature