Control over brain activation and pain learned by using real-time functional MRI.

ABSTRACT: If an individual can learn to directly control activation of localized regions within the brain, this approach might provide control over the neurophysiological mechanisms that mediate behavior and cognition and could potentially provide a different route for treating disease. Control over the endogenous pain modulatory system is a particularly important target because it could enable a unique mechanism for clinical control over pain. Here, we found that by using real-time functional MRI (rtfMRI) to guide training, subjects were able to learn to control activation in the rostral anterior cingulate cortex (rACC), a region putatively involved in pain perception and regulation. When subjects deliberately induced increases or decreases in rACC fMRI activation, there was a corresponding change

SUBMITTER: deCharms RC 

PROVIDER: S-EPMC1311906 | biostudies-literature | 2005 Dec

REPOSITORIES: biostudies-literature