CD8⁺ T Cell Infiltration Elicits Molecular Subtype-Biased Clinical Outcomes in Gastric Cancer Patients.

ABSTRACT: CD8⁺ T cell infiltration is essential for antitumor immunity across cancers while its clinical significance in gastric cancer (GC) remains unclear. This reflects molecular heterogeneity of GC, as defined by The Cancer Genome Atlas (TCGA) into four subtypes: Epstein-Barr virus (EBV)-positive, microsatellite instability (MSI), chromosomal instability (CIN), and genomically stable (GS), each with distinct immune features. We aimed to characterize distribution, clinical relevance, and immune associations of CD8⁺ T cell infiltration within this molecular framework. TCGA (n = 336) and Zhongshan Hospital (ZSHS, n = 455) cohorts were analyzed. CD8⁺ T cell infiltration and immune features were compared across TCGA subtypes. Prognostic and predictive significance of

SUBMITTER: Ling Z 

PROVIDER: S-EPMC13134523 | biostudies-literature | 2026 May

REPOSITORIES: biostudies-literature