Analysis of variation of amplitudes in cell cycle gene expression.

ABSTRACT:

Background

Variation in gene expression among cells in a population is often considered as noise produced from gene transcription and post-transcription processes and experimental artifacts. Most studies on noise in gene expression have emphasized a few well-characterized genes and proteins. We investigated whether different cell-arresting methods have impacts on the maximum expression levels (amplitudes) of a cell cycle related gene.

Results

By introducing random noise, modeled by a von Mises distribution, to the phase angle in a sinusoidal model in a cell population, we derived a relationship between amplitude and the distribution of noise in maximum transcription time (phase). We applied our analysis to Whitfield's HeLa cell cycle data. Our analysis suggests that among 47

SUBMITTER: Liu D 

PROVIDER: S-EPMC1315354 | biostudies-literature | 2005 Nov

REPOSITORIES: biostudies-literature