Endothelial lipase concentrations are increased in metabolic syndrome and associated with coronary atherosclerosis.

ABSTRACT:

Background

Endothelial lipase (EL), a new member of the lipase family, has been shown to modulate high-density lipoprotein (HDL-C) metabolism and atherosclerosis in mouse models. We hypothesized that EL concentrations would be associated with decreased HDL-C and increased atherosclerosis in humans.

Methods and findings

Healthy individuals with a family history of premature coronary heart disease (n = 858) were recruited as part of the Study of the Inherited Risk of Atherosclerosis. Blood was drawn in the fasting state before and, in a subgroup (n = 510), after administration of a single dose of intravenous heparin. Plasma lipids were measured enzymatically, lipoprotein subclasses were assessed by nuclear magnetic resonance, and coronary artery calcification (CAC) was quantif

SUBMITTER: Badellino KO 

PROVIDER: S-EPMC1316064 | biostudies-literature | 2006 Feb

REPOSITORIES: biostudies-literature