Genetic analysis of families with autoimmune diabetes and thyroiditis: evidence for common and unique genes.

ABSTRACT:

Context

Epidemiological data suggest a common genetic susceptibility to type 1 diabetes (T1D) and autoimmune thyroid disease (AITD).

Objective

Our objective was to identify the joint susceptibility genes for T1D and AITD.

Design

We conducted a family-based linkage and association study.

Setting

The study took place at an academic medical center.

Participants

Participants included 55 multiplex families (290 individuals) in which T1D and AITD clustered (T1D-AITD families).

Main outcome measures

We conducted tests for linkage and family-based associations (transmission disequilibrium test) with four candidate genes: human leukocyte antigen (HLA), cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), insulin variable number of tandem repeats (VNTR), a

SUBMITTER: Golden B 

PROVIDER: S-EPMC1317090 | biostudies-literature | 2005 Aug

REPOSITORIES: biostudies-literature