Targeted ablation of plectin isoform 1 uncovers role of cytolinker proteins in leukocyte recruitment.

ABSTRACT: Plectin, a typical cytolinker protein, is essential for skin and skeletal muscle integrity. It stabilizes cells mechanically, regulates cytoskeleton dynamics, and serves as a scaffolding platform for signaling molecules. A variety of isoforms expressed in different tissues and cell types account for this versatility. To uncover the role of plectin 1, the major isoform expressed in tissues of mesenchymal origin, against the background of all other variants, we raised plectin isoform 1-specific antibodies and generated isoform-deficient mice. In contrast to plectin-null mice (lacking all plectin isoforms), which die shortly after birth because of severe skin blistering, plectin isoform 1-deficient mice were viable at birth, had a normal lifespan, and did not display the skin blistering pheno

SUBMITTER: Abrahamsberg C 

PROVIDER: S-EPMC1317913 | biostudies-literature | 2005 Dec

REPOSITORIES: biostudies-literature