Qijia Rougan Formula alleviates liver fibrosis by inhibiting NLRP3-mediated pyroptosis and regulating macrophage polarization.

ABSTRACT:

Background

Stage F3 liver fibrosis represents a critical phase for intercepting the progression toward irreversible cirrhosis. Despite its clinical significance, effective interventions remain scarce. Clinical observations indicate that the traditional Chinese medicine (TCM) formula Qijia Rougan Formula (QRF) exhibits pronounced anti-fibrotic efficacy specifically at Stage F3. Preliminary data suggest that QRF may exert immunomodulatory and anti-fibrotic effects by targeting NLRP3 inflammasome/GSDMD axis. Its precise mechanistic underpinnings warrant further elucidation.

Methods

C57BL/6 mice were administered CCl₄ to establish stage F3 model. Following a 6-week therapeutic regimen, hepatic structural integrity and functional recovery were assessed. A multi-tiered

SUBMITTER: Ding X 

PROVIDER: S-EPMC13183564 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature