The IgA nephropathy Biobank. An important starting point for the genetic dissection of a complex trait.

ABSTRACT:

Background

IgA nephropathy (IgAN) or Berger's disease, is the most common glomerulonephritis in the world diagnosed in renal biopsied patients. The involvement of genetic factors in the pathogenesis of the IgAN is evidenced by ethnic and geographic variations in prevalence, familial clustering in isolated populations, familial aggregation and by the identification of a genetic linkage to locus IGAN1 mapped on 6q22-23. This study seems to imply a single major locus, but the hypothesis of multiple interacting loci or genetic heterogeneity cannot be ruled out. The organization of a multi-centre Biobank for the collection of biological samples and clinical data from IgAN patients and relatives is an important starting point for the identification of the disease susceptibility genes.

SUBMITTER: Schena FP 

PROVIDER: S-EPMC1318455 | biostudies-literature | 2005 Dec

REPOSITORIES: biostudies-literature