Coiled-coil protein composition of 22 proteomes--differences and common themes in subcellular infrastructure and traffic control.

ABSTRACT:

Background

Long alpha-helical coiled-coil proteins are involved in diverse organizational and regulatory processes in eukaryotic cells. They provide cables and networks in the cyto- and nucleoskeleton, molecular scaffolds that organize membrane systems and tissues, motors, levers, rotating arms, and possibly springs. Mutations in long coiled-coil proteins have been implemented in a growing number of human diseases. Using the coiled-coil prediction program MultiCoil, we have previously identified all long coiled-coil proteins from the model plant Arabidopsis thaliana and have established a searchable Arabidopsis coiled-coil protein database.

Results

Here, we have identified all proteins with long coiled-coil domains from 21 additional fully sequenced genomes. Because regions

SUBMITTER: Rose A 

PROVIDER: S-EPMC1322226 | biostudies-literature | 2005 Nov

REPOSITORIES: biostudies-literature