The global transcriptional regulatory network for metabolism in Escherichia coli exhibits few dominant functional states.

ABSTRACT: A principal aim of systems biology is to develop in silico models of whole cells or cellular processes that explain and predict observable cellular phenotypes. Here, we use a model of a genome-scale reconstruction of the integrated metabolic and transcriptional regulatory networks for Escherichia coli, composed of 1,010 gene products, to assess the properties of all functional states computed in 15,580 different growth environments. The set of all functional states of the integrated network exhibits a discernable structure that can be visualized in 3-dimensional space, showing that the transcriptional regulatory network governing metabolism in E. coli responds primarily to the available electron acceptor and the presence of glucose as the carbon source. This result is consistent with recen

SUBMITTER: Barrett CL 

PROVIDER: S-EPMC1323155 | biostudies-literature | 2005 Dec

REPOSITORIES: biostudies-literature