Structural genomics analysis of alternative splicing and application to isoform structure modeling.

ABSTRACT: Alternative splicing is a sophisticated nuclear process that regulates gene expression. It represents an important mechanism for enhancing the functional diversity of proteins. Our current knowledge of alternatively spliced variants is derived mainly from mRNA transcripts, and very little is known about their protein tertiary structures. We carried out a large-scale analysis of known alternatively spliced variants at both protein sequence and structure levels and have shown that threading is, in general, a viable approach for modeling structures of alternatively spliced variants. An examination of alternative splicing at the protein sequence level revealed that the size of splicing events follows the power law distribution and the majority of splicing isoforms harbor only one or two altern

SUBMITTER: Wang P 

PROVIDER: S-EPMC1323168 | biostudies-literature | 2005 Dec

REPOSITORIES: biostudies-literature