PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry.

ABSTRACT: Previous studies have demonstrated that a small subpopulation of brain tumor cells share key characteristics with neural stem/progenitor cells in terms of phenotype and behavior. These findings suggest that brain tumors might contain "cancer stem cells" that are critical for tumor growth. However, the molecular pathways governing such stem cell-like behavior remain largely elusive. Our previous study suggests that the phosphatase and tensin homologue deleted on chromosome 10 (PTEN) tumor suppressor gene, one of the most frequently mutated genes in glioblastomas, restricts neural stem/progenitor cell proliferation in vivo. In the present study, we sought to determine the role of PTEN in long-term maintenance of stem cell-like properties, cell cycle entry and progression, and growth factor d

SUBMITTER: Groszer M 

PROVIDER: S-EPMC1325011 | biostudies-literature | 2006 Jan

REPOSITORIES: biostudies-literature