Randomised placebo controlled multicentre trial to assess short term clarithromycin for patients with stable coronary heart disease: CLARICOR trial.

ABSTRACT:

Objective

To determine if the macrolide clarithromycin affects mortality and cardiovascular morbidity in patients with stable coronary heart disease.

Design

Centrally randomised multicentre trial. All parties at all stages were blinded. Analyses were by intention to treat.

Setting

Five Copenhagen University cardiology departments and a coordinating centre.

Participants

13,702 patients aged 18 to 85 years who had a discharge diagnosis of myocardial infarction or angina pectoris in 1993-9 and alive in August 1999 were invited by letter; 4373 were randomised.

Interventions

Two weeks' treatment with clarithromycin 500 mg/day or matching placebo.

Main outcome measures

Primary outcome

composite of all cause mortality, myocardial infarction, or u

SUBMITTER: Jespersen CM 

PROVIDER: S-EPMC1325128 | biostudies-literature | 2006 Jan

REPOSITORIES: biostudies-literature