Comparative analysis of programmed cell death pathways in filamentous fungi.

ABSTRACT:

Background

Fungi can undergo autophagic- or apoptotic-type programmed cell death (PCD) on exposure to antifungal agents, developmental signals, and stress factors. Filamentous fungi can also exhibit a form of cell death called heterokaryon incompatibility (HI) triggered by fusion between two genetically incompatible individuals. With the availability of recently sequenced genomes of Aspergillus fumigatus and several related species, we were able to define putative components of fungi-specific death pathways and the ancestral core apoptotic machinery shared by all fungi and metazoa.

Results

Phylogenetic profiling of HI-associated proteins from four Aspergilli and seven other fungal species revealed lineage-specific protein families, orphan genes, and core genes conserved acro

SUBMITTER: Fedorova ND 

PROVIDER: S-EPMC1325252 | biostudies-literature | 2005 Dec

REPOSITORIES: biostudies-literature