Increased synaptic microtubules and altered synapse development in Drosophila sec8 mutants.

ABSTRACT:

Background

Sec8 is highly expressed in mammalian nervous systems and has been proposed to play a role in several aspects of neural development and function, including neurite outgrowth, calcium-dependent neurotransmitter secretion, trafficking of ionotropic glutamate receptors and regulation of neuronal microtubule assembly. However, these models have never been tested in vivo. Nervous system development and function have not been described after mutation of sec8 in any organism.

Results

We identified lethal sec8 mutants in an unbiased forward genetic screen for mutations causing defects in development of glutamatergic Drosophila neuromuscular junctions (NMJs). The Drosophila NMJ is genetically malleable and accessible throughout development to electrophysiology and immunocy

SUBMITTER: Liebl FL 

PROVIDER: S-EPMC1326216 | biostudies-literature | 2005 Dec

REPOSITORIES: biostudies-literature