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Stat5a/b are essential for normal lymphoid development and differentiation.

ABSTRACT: Cytokines that use the common gamma chain gammac are critical for lymphoid development and function. Mutations of the IL-7 receptor, gammac, or its associated kinase, Jak3, are the major cause of human severe combined immunodeficiency. Although activated by IL-7, Stat5a/b (Stat, signal transducer and activator of transcription) have been thought to play limited roles in lymphoid development. However, we now show that mice completely deficient in Stat5a/b have severely impaired lymphoid development and differentiation. Absence of Stat5 also abrogates T cell receptor gamma rearrangement and survival of peripheral CD8(+) T cells. Thus, deficiency of Stat5 results in severe combined immunodeficiency, similar in many respects to deficiency of IL-7R, gammac, and Jak3.

SUBMITTER: Yao Z

PROVIDER: S-EPMC1327727 | biostudies-literature | 2006 Jan

REPOSITORIES: biostudies-literature

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Stat5a/b are essential for normal lymphoid development and differentiation.

Yao Zhengju Z Cui Yongzhi Y Watford Wendy T WT Bream Jay H JH Yamaoka Kunihiro K Hissong Bruce D BD Li Denise D Durum Scott K SK Jiang Qiong Q Bhandoola Avinash A Hennighausen Lothar L O'Shea John J JJ

Proceedings of the National Academy of Sciences of the United States of America 20060117 4

Cytokines that use the common gamma chain gammac are critical for lymphoid development and function. Mutations of the IL-7 receptor, gammac, or its associated kinase, Jak3, are the major cause of human severe combined immunodeficiency. Although activated by IL-7, Stat5a/b (Stat, signal transducer and activator of transcription) have been thought to play limited roles in lymphoid development. However, we now show that mice completely deficient in Stat5a/b have severely impaired lymphoid developme ...[more]

PMID: 16418296

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