AI-Augmented Hematological Signatures for Equitable Detection of Hereditary Hemolytic Anemia Carriers: A Global Systematic Review and Meta-Analysis.

ABSTRACT: Artificial intelligence (AI) augmentation of routine hematological tests offers a promising strategy to improve hereditary hemolytic anemia (HHA) carrier detection in premarital screening, especially in resource-limited settings. HHA in this review specifically encompasses β-thalassemia, α-thalassemia, sickle cell disease (including HbS and HbC variants), and other hemoglobinopathies with autosomal recessive inheritance patterns requiring carrier detection for prevention. These conditions share hemolytic phenotypes but differ in hematological signatures, necessitating separate subgroup analyses. This global systematic review and meta-analysis evaluated the diagnostic accuracy, equity implications, and implementation challenges of AI-augmented complete blood count (CBC), blood

SUBMITTER: Ali NT 

PROVIDER: S-EPMC13309745 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature