Causal Association Between Thyroid Function and Myeloproliferative Disease: A Two-Sample Mendelian Randomization Study.

ABSTRACT:

Background

Thyroid dysfunction has been linked to hematologic abnormalities, but whether thyroid function has a causal role in myeloproliferative diseases (MDs), including chronic myeloproliferative disease (CMD), remains unclear. We used Mendelian randomization (MR) to assess the potential causal effects of thyroid-related traits on MD risk.

Methods

A two-sample MR analysis was performed using genome-wide association study (GWAS) summary statistics. Outcome data for CMD and MD, excluding chronic myelogenous leukemia (CML), were obtained from the Finnish R12 cohort (European ancestry). Genetic instruments for thyroid traits-including thyrotropin (TSH), free thyroxine (FT4), free/total triiodothyronine (FT3/TT3), FT3/FT4 and TT3/FT4 ratios, high/low TSH, and genetic liability

SUBMITTER: Xiang J 

PROVIDER: S-EPMC13309939 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature