Alterations of renal phenotype and gene expression profiles due to protein overload in NOD-related mouse strains.

ABSTRACT:

Background

Despite multiple causes, Chronic Kidney Disease is commonly associated with proteinuria. A previous study on Non Obese Diabetic mice (NOD), which spontaneously develop type 1 diabetes, described histological and gene expression changes incurred by diabetes in the kidney. Because proteinuria is coincident to diabetes, the effects of proteinuria are difficult to distinguish from those of other factors such as hyperglycemia. Proteinuria can nevertheless be induced in mice by peritoneal injection of Bovine Serum Albumin (BSA). To gain more information on the specific effects of proteinuria, this study addresses renal changes in diabetes resistant NOD-related mouse strains (NON and NOD.B10) that were made to develop proteinuria by BSA overload.

Methods

Proteinuria was

SUBMITTER: Wilson KH 

PROVIDER: S-EPMC1334202 | biostudies-literature | 2005 Dec

REPOSITORIES: biostudies-literature