Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers.

ABSTRACT:

Background

Inadequate oxygen (hypoxia) triggers a multifaceted cellular response that has important roles in normal physiology and in many human diseases. A transcription factor, hypoxia-inducible factor (HIF), plays a central role in the hypoxia response; its activity is regulated by the oxygen-dependent degradation of the HIF-1alpha protein. Despite the ubiquity and importance of hypoxia responses, little is known about the variation in the global transcriptional response to hypoxia among different cell types or how this variation might relate to tissue- and cell-specific diseases.

Methods and findings

We analyzed the temporal changes in global transcript levels in response to hypoxia in primary renal proximal tubule epithelial cells, breast epithelial cells, smooth muscle

SUBMITTER: Chi JT 

PROVIDER: S-EPMC1334226 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature