The Escherichia coli glucose transporter enzyme IICB(Glc) recruits the global repressor Mlc.

ABSTRACT: In addition to effecting the catalysis of sugar uptake, the bacterial phosphoenolpyruvate:sugar phosphotransferase system regulates a variety of physiological processes. Exposure of cells to glucose can result in repression or induction of gene expression. While the mechanism for carbon catabolite repression by glucose was well documented, that for glucose induction was not clearly understood in Escherichia coli. Recently, glucose induction of several E.coli genes has been shown to be mediated by the global repressor Mlc. Here, we elucidate a general mechanism for glucose induction of gene expression in E.coli, revealing a novel type of regulatory circuit for gene expression mediated by the phosphorylation state-dependent interaction of a membrane-bound protein with a repressor. The dephos

SUBMITTER: Nam TW 

PROVIDER: S-EPMC133465 | biostudies-literature | 2001 Feb

REPOSITORIES: biostudies-literature