A Programmable Calcification Nanoplatform for Loco-Regional Calcification-Immune Hepatocellular Carcinoma Therapy.

ABSTRACT: Inducing tumor calcification is a promising strategy for disrupting cancer progression, yet achieving efficient biomineralization with synergistic antitumor effects remains challenging. Here, a programmable calcification nanoplatform (CaIM) is developed using in situ growth of calcium peroxide (CaO₂) on black phosphorus (BP) nanosheets, followed by hyaluronic acid encapsulation. Unlike conventional physical adsorption or co-precipitation, this in situ growth strategy yields crystalline CaO₂ uniformly anchored on the BP matrix, enabling synchronized release of Ca^{2 +}, phosphate, and H₂O₂ in the tumor microenvironment. CaIM induces potent intracellular calcium overload and oxidative stress, triggering mitochondrial dysfunction,

SUBMITTER: Liu L 

PROVIDER: S-EPMC13383153 | biostudies-literature | 2026 Oct

REPOSITORIES: biostudies-literature