Early Dapagliflozin and Melatonin Treatment Ameliorated LV Fibrosis via Suppressing TGF-β1/Smads and Activating Nrf2-ARE Signaling in MI Rodent.

ABSTRACT: This study tested whether combined dapagliflozin (DAPA) and melatonin (Mel) therapy was superior to merely one for ameliorating the left ventricular (LV) fibrosis/remodeling and improving LV ejection fraction (LVEF) in rats after acute myocardial infarction (AMI). In vitro study demonstrated that DAPA treatment significantly suppressed the TGF-β/Smads signaling, whereas Mel treatment significantly upregulated Nrf2/ARE signaling in ischemia-reperfusion (IR) H9C2 cells (all P< 0.001). Additionally, simultaneously silencing TGF-β and overexpression of Nrf2 in H9C2 cells significantly suppressed fibrotic and upregulated antioxidant signaling (all P< 0.001). Adult male Sprague-Dawley rats were categorized into groups 1 (sham-operated-control)/2 (AMI)/3 (AMI + DAPA)/4 (AMI + Mel)/5 (AMI + DAPA-M

SUBMITTER: Sheu JJ 

PROVIDER: S-EPMC13399667 | biostudies-literature | 2026 Oct

REPOSITORIES: biostudies-literature