Inflammatory Signaling and Emotional Symptoms in Hashimoto's Thyroiditis beyond Thyroid Function Status.

ABSTRACT:

Introduction: Patients with Hashimoto's thyroiditis (HT) frequently report persistent emotional and cognitive symptoms even when thyroid hormone levels are within the reference range. The mechanisms underlying these symptoms beyond thyroid function status remain incompletely understood. This study aimed to characterize the symptom profile of HT patients with thyroid hormone levels within the reference ranges and to investigate whether peripheral inflammatory signaling is associated with emotional symptoms independent of thyroid-related factors.

Methods

Clinical data were analyzed from 80 patients with HT whose free triiodothyronine and free thyroxine levels were within the reference ranges and who did not have suppressed thyroid-stimulating hormone (TSH). Thyroid-related quality

SUBMITTER: Yao S 

PROVIDER: S-EPMC13441259 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature