A human mitochondrial transcription factor is related to RNA adenine methyltransferases and binds S-adenosylmethionine.

ABSTRACT: A critical step toward understanding mitochondrial genetics and its impact on human disease is to identify and characterize the full complement of nucleus-encoded factors required for mitochondrial gene expression and mitochondrial DNA (mtDNA) replication. Two factors required for transcription initiation from a human mitochondrial promoter are h-mtRNA polymerase and the DNA binding transcription factor, h-mtTFA. However, based on studies in model systems, the existence of a second human mitochondrial transcription factor has been postulated. Here we report the isolation of a cDNA encoding h-mtTFB, the human homolog of Saccharomyces cerevisiae mitochondrial transcription factor B (sc-mtTFB) and the first metazoan member of this class of transcription factors to which a gene has been assign

SUBMITTER: McCulloch V 

PROVIDER: S-EPMC134642 | biostudies-literature | 2002 Feb

REPOSITORIES: biostudies-literature