The ompA gene in Chlamydia trachomatis differs in phylogeny and rate of evolution from other regions of the genome.

ABSTRACT: Strains of Chlamydia trachomatis are classified into serovars based on nucleotide sequence differences in ompA, the gene that encodes the major outer membrane protein. Phylogenetic characterization of strains based on ompA, however, results in serovar groupings that are inconsistent with the distinguishing features of C. trachomatis pathobiology, e.g., tissue tropisms and disease presentation. We have compared nucleotide sequences at multiple sites distributed around the chlamydial genome from 18 strains representing 16 serovars; sampled regions included genes encoding housekeeping enzymes (totaling 2,073 bp), intergenic noncoding segments (1,612 bp), and a gene encoding a second outer membrane protein (porB; 1,023 bp), with the ompA sequence (1,194 bp) used for reference. These comparativ

SUBMITTER: Brunelle BW 

PROVIDER: S-EPMC1346613 | biostudies-literature | 2006 Jan

REPOSITORIES: biostudies-literature