Transcriptional profiling of Mycoplasma hyopneumoniae during heat shock using microarrays.

ABSTRACT: Bacterial pathogens undergo stress during host colonization and disease processes. These stresses result in changes in gene expression to compensate for potentially lethal environments developed in the host during disease. Mycoplasma hyopneumoniae colonizes the swine epithelium and causes a pneumonia that predisposes the host to enhanced disease from other pathogens. How M. hyopneumoniae responds to changing environments in the respiratory tract during disease progression is not known. In fact, little is known concerning the capabilities of mycoplasmas to respond to changing growth environments. With limited genes, mycoplasmas are thought to possess only a few mechanisms for gene regulation. A microarray consisting of 632 of the 698 open reading frames of M. hyopneumoniae was constructed a

SUBMITTER: Madsen ML 

PROVIDER: S-EPMC1346651 | biostudies-literature | 2006 Jan

REPOSITORIES: biostudies-literature