Neutralization escape variants of human immunodeficiency virus type 1 are transmitted from mother to infant.

ABSTRACT: Maternal passive immunity typically plays a critical role in protecting infants from new infections; however, the specific contribution of neutralizing antibodies in limiting mother-to-child transmission of human immunodeficiency virus type 1 is unclear. By examining cloned envelope variants from 12 transmission pairs, we found that vertically transmitted variants were more resistant to neutralization by maternal plasma than were maternal viral variants near the time of transmission. The vertically transmitted envelope variants were poorly neutralized by monoclonal antibodies b12 [corrected] 2G12, 2F5, and 4E10 individually or in combination. Despite the fact that the infant viruses were among the most neutralization resistant in the mother, they had relatively few glycosylation sites. Mor

SUBMITTER: Wu X 

PROVIDER: S-EPMC1346878 | biostudies-literature | 2006 Jan

REPOSITORIES: biostudies-literature