Ontology highlight
ABSTRACT:
SUBMITTER: Robert F
PROVIDER: S-EPMC1346889 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Robert Flavie F Hardy Sara S Nagy Zita Z Baldeyron Céline C Murr Rabih R Déry Ugo U Masson Jean-Yves JY Papadopoulo Dora D Herceg Zdenko Z Tora Làszlò L
Molecular and cellular biology 20060101 2
Transactivation-transformation domain-associated protein (TRRAP) is a component of several multiprotein histone acetyltransferase (HAT) complexes implicated in transcriptional regulation. TRRAP was shown to be required for the mitotic checkpoint and normal cell cycle progression. MRE11, RAD50, and NBS1 (product of the Nijmegan breakage syndrome gene) form the MRN complex that is involved in the detection, signaling, and repair of DNA double-strand breaks (DSBs). By using double immunopurificatio ...[more]