Bidirectional virus secretion and nonciliated cell tropism following Andes virus infection of primary airway epithelial cell cultures.

ABSTRACT: Hantavirus pulmonary syndrome (HPS) is an acute disease resulting from infection with any one of a number of New World hantaviruses. HPS has a mortality rate of 40% and, unlike many other severe respiratory diseases, often occurs in young, healthy adults. Infection is usually initiated after inhalation of rodent excreta containing virus particles, but human-to-human transmission has been documented. Postmortem tissue samples show high levels of viral antigen within the respiratory endothelium, but it is not clear how the virus can traverse the respiratory epithelium in order to initiate infection in the microvasculature. We have utilized Andes virus infection of primary, differentiated airway epithelial cells to investigate the ability of the virus to interact with and cross the respirator

SUBMITTER: Rowe RK 

PROVIDER: S-EPMC1346943 | biostudies-literature | 2006 Feb

REPOSITORIES: biostudies-literature